Manchester United will travel to Spain to take on Valencia at the Mestalla Stadium on the back of an emphatic 4-1 victory over Fulham last weekend. The Red Devils have already booked their place in the UEFA Champions League Round of 16 and could go top of their group with a win in midweek.
However, Jose Mourinho is expected to make a whole host of changes for this game so that some of his first-team starters can get some rest in order to be fresh and ready for the trip to Liverpool this weekend.
United might line up in a 4-3-3 formation with Sergio Romero starting in between the sticks in place of David De Gea.
4-3-3 Manchester United Predicted Lineup To Face Valencia
Sergio Romero could get a rare chance to start in goal for the Red Devils as Mourinho might want to hand David De Gea a well deserved rest. The Argentine keeper has just made one appearance for United this season when he was sent off against Derby County in the EFL Cup. He will hope for a much better outing against Valencia on Wednesday night.
The defensive pair of Marcos Rojo and Phil Jones might lineup in central defence in the absence of the injured Victor Lindelof. Both Chris Smalling and Eric Bailly are significant doubts for this clash so Mourinho might choose to leave them out in midweek. Matteo Darmian might be deployed in the left-back position while Antonio Valencia could assume his role as the right-back.
Luke Shaw is also on the injury list and is expected to not travel for this encounter in Spain.
Mourinho could opt for the midfield trio of Fred, Scott McTominay and Marouane Fellaini as he is likely to rest some of his first-team starters ahead of the crucial match against Liverpool this weekend.
Paul Pogba might be available on the bench and could be utilised during the match if required.
The Man United front three could be comprised of Andreas Pereira, Marcus Rashford and Angel Gomes. Alexis Sanchez is currently sidelined due to an injury which means that Rashford could get a chance to lead the line for the Mancunian giants while both Pereira and Gomes tries to support him from the wide areas.