Midfield
Santi Cazorla’s injury is a bit of a mystery at the moment and it is unclear of he is fit for the match or not.
In any case, Wenger is known to give ample rest time to players before bringing them on the pitch and we expect Cazorla to rest this match.
While it was quite visible that two box to box midfielders a the center- Francis Coquelin and Mohamed Elneny didn’t click so well against Middlesbrough, Wenger might have to try something else this time.
Up front Mesut Ozil is expected to take his place flanked by Alex Iwobi and Theo Walcott.
There have been floating reports of Walcott being unwell and in such a scenario, Chamberlain is sure to take his place after his goal scoring performance in the midweek.
Attack
Alexis Sanchez has been phenomenal this season up front with 4 goals in 9 appearances and there is no reason Wenger is replacing him.
The return of Olivier Giroud in the midweek increases options for Wenger and another dimension of attacking.