Oriol Romeu will certainly start in midfield. He has been a key player for the Saints this season with his overall contribution to the game and must ensure that he has a good outing against Everton to win his side the game.
We expect Steven Davis to start alongside the Spaniard in midfield.
Dusan Tadic is expected to start as the number ten.
Southampton played 4-3-3 against West Brom in the last game but with Redmond coming back from injury, Tadic will be released from his duty on the right wing and slot into an advanced midfield position.
Nathan Redmond will take his place on the right flank.
Jay Rodriguez is likely to start up front despite Shane Long scoring his first goal of the season against West Brom on Saturday.
Sofiane Boufal will keep his place on the left flank.