Arsene Wenger is ready to leave out Alexis Sanchez for the FA Cup clash with Southampton. Mesut Ozil will also be given a rest as Wenger wants them to be fresh for the Premier League.
Although it is very normal to rotate the squad but the actual thing might be different. Sanchez recently expressed his frustration on two occasions and the decision might be its outcome.
Danny Welbeck who has just returned from injury could be involved alongside Lucas Perez who has been very impressive for the Gunners.
Theo Walcott is also ready for some game time as he is on his way to gain full fitness after suffering from a calf problem.
At the Gunners goal, David Ospina is almost certain to replace Peter Cech.
In the defence, Hector Bellerin and Kieran Gibbs are expected to start while Francis Coquelin could replace the suspended Granit Xhaka.